Friday, September 28, 2018

THE ENDOCANNABINOID SYSTEM(ECS)LARGEST NEUROTRANSMITTER SYSTEM IN THE BODY, NOT TAUGHT IN MEDICAL SCHOOL.

The Endocannabinoid System (ECS)
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The largest neurotransmitter system in the body, that is not taught in medical school.



“Our Endocannabinoid System [ECS] regulates everything in our body. Our Immune system, digestive system, cardiovascular system, nervous system, endocrine system, skin, skeleton, everything in our body is homeostatically regulated by our Endocannabinoid System. And yet it’s not taught in medical schools? There’s something a little flawed here...”
- Dr. Bob Melamede


Repeated stress impairs endocannabinoid signaling…  (physical stress, TOXINS,  PTSD etc)
https://goo.gl/cHPqBU

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“Mammalian cells have machinery, the so called Endocannabinoid system (ECS), to produce and metabolize their own cannabinoids in order to control homeostasis of the gut in a rapidly adapting manner.”
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Division of Gastroenterology, Department of Medicine, University of Calgary

The endogenous cannabinoid system—named for the plant [cannabis] that led to its discovery—is one of the most important physiologic systems involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. With its complex actions in our immune system, nervous system, and virtually all of the body’s organs, the endocannabinoids are literally a bridge between body and mind. By understanding this system, we begin to see a mechanism that could connect brain activity and states of physical health and disease.”
-Bradley E. Alger, Ph.D.

"Honest doctors can no longer practice honest medicine, we have a complete healthcare system failure and an epidemic of misinformed doctors and misinformed and harmed patients."
- Dr. Aseem Malhotra

Ask Your Doctor this question to test if they fully are aware of ECS

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Simple Layout Research Quotes (PDF slideshow)


Memory Storage & Encoding  (PDF)

Endocannabinoid System Reward System


Dr Ross - Neuroscientist - Clinical Endocannabinoid Deficiency (CECD)
https://goo.gl/kWQLR8

Dr Ross - Vitamin Weed
https://goo.gl/VVT9YX
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Dr. Uma Dhanabalan MD MPH FAAFP MRO speaking about ECS at Senate Medical Affairs committee


Here's exactly how medical marijuana works in the body
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"The body also produces its own cannabinoid chemicals [fat like lipids].  They play a role in regulating pleasure, memory, thinking, concentration, body movement, awareness of time, appetite, pain, and the senses (taste, touch, smell, hearing, and sight)."
- National Institute of Drug Abuse



“In the last 25 years a good deal of information has been accumulated on the main components of the "endocannabinoid (eCB) system", a rather complex ensemble of lipid signals ("endocannabinoids"), their target receptors, purported transporters, and metabolic enzymes. It has been clearly documented that eCB signaling plays a key role in many human health and disease conditions of the central nervous system, thus opening the avenue to the therapeutic exploitation of eCB-oriented drugs for the treatment of psychiatric, neurodegenerative, and neuroinflammatory disorders.”

- Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.
- Center of Integrated Research and School of Medicine, Campus Bio-Medico University of Rome.
- Mafalda Luce Center for Pervasive Developmental Disorders, Milan, Italy.
- Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
- Center of Integrated Research and School of Medicine, Campus Bio-Medico University of Rome,
- European Center for Brain Research (CERC)/Santa Lucia Foundation, Rome, Italy.


Marijuana and Coffee are good for the Brain
Aging Brings Inflammation to the Brain
Professor Gary Wenk
Professor of psychology and neuroscience at The Ohio State University
https://www.youtube.com/watch?v=2uVXs6CY2ps

Clinical Endocannabinoid Deficiency list of research (CECD)
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Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?

Wired to Run - Endocannabinoid Signaling

Obesity & ECS

Cancer & ECS
https://goo.gl/wNTpQe

Autism & ECS

Skin & ECS

Pain & ECS

Parkinson’s Disease & ECS




"Cannabinoids appear to kill tumor cells but do not affect their non-transformed counterparts and may even protect them from cell death. "
-National Cancer Institute
https://goo.gl/Xnv9B9

So depression is an inflammatory diseases, but where does the inflammation come from?
https://goo.gl/45L2pH

Targeting Cutaneous Cannabinoid Signaling in Inflammation - A “High”-way to Heal?

https://goo.gl/jpMYJz

Cannabinoids in Breast milk
https://goo.gl/NzZLbm
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National Institute of Health
https://goo.gl/MmzQPa
https://goo.gl/6vdjwd (National Institute of Health attached image dysregulation of ECS)

Inflammation in Health and Disease Research Quotes
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The Endocannabinoid System Research Quotes High Resolution Poster (IMAGE)
https://goo.gl/gFKccS


“The endocannabinoid (eCB) system consists of ligands, such as anandamide and 2-arachidonoyl-glycerol (2-AG), receptors (e.g. CB1, CB2), transporters and enzymes, which are responsible for the ‘on-demand’ synthesis and degradation of these lipid mediators. There is a large body of evidence showing that eCB are markedly increased in response to pathogenic events. This fact, as well as numerous studies on experimental models of brain toxicity, neuroinflammation and trauma supports the notion that the eCB are part of the brain's compensatory or repair mechanisms.”

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Endocannabinoids modulate human blood-brain barrier permeability in vitro.
“Anandamide [endocannabinoid similar to cannabis’ THC] (10 μM) and oleoylethanolamide (OEA, 10 μM) decreased BBB [Blood Brain Barrier] permeability (i.e. increased resistance). “
https://goo.gl/m47y7C

Blood Brain Barrier (BBB) in embryos and Newborns
"These interfaces are referred to as “the” blood–brain barrier. It is widely believed that in embryos and newborns, this barrier is immature or “leaky,” rendering the developing brain more vulnerable to drugs or toxins entering the fetal circulation from the mother."

https://goo.gl/bafVqS
- The University of Melbourne,
- Cedars-Sinai Medical Center, USA

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“Recently, an accumulating body of evidence has implicated the endocannabinoid system in the etiology of PTSD, and targets within this system are believed to be suitable for treatment development.“. .

“There is convincing evidence from multiple studies for reduced endocannabinoid availability in PTSD.“. .

“Of particular relevance is evidence showing  reduced levels of the endocannabinoid anandamide”...

- Department of Psychiatry, New York University School of Medicine
- United States Department of Veterans Affairs National Center for Posttraumatic Stress Disorder

This review gives an overview of the CB2 [cannabinoid 2] receptor (CB2R) knockout (CB2R−/−) mice phenotype and the work that has been carried out using this mutant mouse. Using the CB2R−/− mice, investigators have discovered the involvement of CB2R [cannabinoid 2 receptor] on immune cell function and development, infection, embryonic development, bone loss, liver disorders, pain, autoimmune inflammation, allergic dermatitis, atherosclerosis, apoptosis and chemotaxis.”
-Department of Biological Sciences, California State Polytechnic University
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“An accumulating body of evidence suggests that the endocannabinoid system plays a significant role in pathophysiological processes and impacts disease severity. Here we investigate the possible role of a cannabinoid receptor type 2 (CB2) functional variant in determining disease severity and the potential pharmacological therapeutic effects of CB2 activation in viral respiratory infection.”..

”The frequency distribution of respiratory syncytial virus (RSV)-the main cause of severe cases of bronchiolitis and pneumonia in children-was studied in all collected samples.”...

”CB2 activation by JWH133 reduces the influx of BAL cells and production of cytokines/chemokines while alleviating lung pathology. Collectively, CB2 is associated with RSV severity during infancy and may serve as a therapeutic target in RSV infection through the alleviation of virus-associated immunopathology.”

JWH-133 is a potent selective CB₂ receptor agonist


Brain Disorders, Autism,  Schizophrenia, Major Depressive Disorder,  PTSD, and Bi Polar.
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"The empirical evidence reviewed strongly supports the role for dysregulated cannabinoid signaling in the pathophysiology of social functioning deficits observed in brain disorders, such as autism spectrum disorder, schizophrenia, major depressive disorder, posttraumatic stress disorder and bipolar disorder. Moreover, these findings indicate that the endogenous cannabinoid system holds exceptional promise as a biological marker of, and potential treatment target for, neuropsychiatric and neurodevelopmental disorders characterized by impairments in social functioning."

- Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences / Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences
Stanford University School of Medicine

Mother Credits Marijuana For Transforming Son With Severe Autism

Dr. James Bradstreet Endocannabinoid System / Cannabis Oils
https://www.youtube.com/watch?v=2hvD5vh2cec

Acetaminophen, Tylenol, Paracetamol
Synthetic cannabinoids / cannabinoid uptake inhibitor
Dangers of Acetaminophen (Synthetic cannabinoids / cannabinoid uptake inhibitor)



“Between 1998 and 2003, acetaminophen was the leading cause of acute liver failure in the US. There are also hundreds of related deaths every year — though keep in mind that millions of people take drugs with acetaminophen, so these more extreme side effects are rare (especially if you're only taking them in small doses occasionally). Still, for the drug's minimal pain-killing benefits, the risks may not be worth it.”
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“Our findings suggest that cannabis use is associated with a reduced incidence of liver disease in alcoholics.”


“The medical profession is being bought by the pharmaceutical industry, not only in terms of the practice of medicine, but also in terms of teaching and research. The academic institutions of this country are allowing themselves to be the paid agents of the pharmaceutical industry. I think it’s disgraceful”
https://medium.com/@drjasonfung/the-corruption-of-evidence-based-medicine-killing-for-profit-41f2812b8704

Google Drive Saved Research on ECS / Cannabinoids
https://goo.gl/SYgdDe
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Definitions


Endocannabinoids are fat like lipids made on demand by the body metabolized from a balanced diet of omegas however a number of things can affect the production of endocannabinoids in the body. Endogenous (endo) meaning made from within. Other terms used for Endocannabinoids are lipid mediators and lipid messengers.

Phytocannabinoids plant derived cannabinoids (also fat like lipids similar to the lipids made by the body) made abundantly on the cannabis plant, and also found in smaller amounts in hemp and other plants.

CB1 - Cannabinoid Receptor 1
CB2 - Cannabinoid Receptor 2








3 comments:

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